Introducing the graveyard shift of CSI Las Vegas. Warrick Brown and Catherine Willows work a domestic disturbance, Nick Stokes investigates a trick-roll victim, Gil Grissom and Jim Brass try and solve a supposed suicide. However, all things are put on hold when Holly Gibbs is reported shot in the line of duty.
The beat goes on as CSI Holly Gribbs remains in critical condition. Grissom and Nick team up to solve the murder of a jackpot winner and Sara Sidle, comes to Las Vegas per Grissom's request to figure out what exactly happened to Holly, with help from Catherine Willows.
As Sara Sidle joins the team Nick, Gil, Sara, and Jim investigates a kidnapping of a millionaires wife while Warrick and Catherine try and find a suspect in a child's hit and run.
Gil and Catherine work a floater found by two fishermen, Sara and Nick investigate the supposed suicide of a pledge to a fraternity. Meanwhile, Warrick Brown has to deal with a corrupt judge who is using him to get a rape case thrown out.
Warrick and Gil investigate the dead body of a young man out in the desert while Sara goes solo on a bizarre case involving a woman's body who was supposed to be buried a week ago. Catherine and Nick work a case where a dean of a school is founded beaten too death in his office with a fellow teacher as the only suspect.
Catherine violates department protocol when she takes the case of a rape accusation against her ex-husband. Warrick and Sara search for the missing bullet that will either exonerate or indict a cop for murder. Grissom and Nick investigate when a female skeleton is found under a house buried in cement.
When a teenager and her sister are the sole survivors of the gruesome murder of four members of one family in a quiet suburban neighborhood, Grissom and his entire team investigate the crime. What initially looks like a bizarre cult murder becomes more disturbing when they discover the motive behind the massacre.
Royce Harmon was murdered 3 months ago in a scene staged to look like a suicide. Now another murder has taken place. Whoever the killer is he has a thorough knowledge of forensics, he purposefully has left evidence, and has baffled Grissom and his team. Warrick and Nick investigate the case of a man who went over a cliff in his car and is now unconscious.
Grissom and his team investigate the death of a first class passenger on a flight to Las Vegas. The investigators are forced not only to examine the physical evidence, but also to interview all of the first class passengers to get their personal accounts of the incident.
Grissom and Sara investigate a bug riddled body found in the desert. Warrick and Catherine look in to the theft of some valuable art. Nick gets to find out why a missing woman's car is found at the bus station. Warrick is suspected of having gambled on duty.
A woman is abducted from a supermarket. In the store, Grissom finds a bathroom stall door that claims five women have been killed. Warrick is caught in a casino on duty and is paired with a reluctant Sara. Their case is the apparent murder and robbery of a man who is found by his brother. Nick gets pulled in by his prostitute friend who gets in a scuffle with hotel security.
A man about to go on trial for arson and the murder of his wife and child seeks assistance from Grissom to help prove his innocence. Meanwhile, Catherine and Nick investigate the underground world of sports gambling when a teenager is murdered at close range.
